Search results for " favore arm"

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Evidence of bias in randomized clinical trials of hepatitis C interferon therapies

2017

Introduction: Bias may occur in randomized clinical trials in favor of the new experimental treatment because of unblinded assessment of subjective endpoints or wish bias. Using results from published trials, we analyzed and compared the treatment effect of hepatitis C antiviral interferon therapies experimental or control. Methods: Meta-regression of trials enrolling naïve hepatitis C virus patients that underwent four therapies including interferon alone or plus ribavirin during past years. The outcome measure was the sustained response evaluated by transaminases and/or hepatitis C virus-RNA serum load. Data on the outcome across therapies were collected according to the assigned arm (exp…

Adultmedicine.medical_specialtyAlternative medicineAntiviral Agentslaw.invention03 medical and health sciences0302 clinical medicineRandomized controlled trialBiaslawInterferonInternal medicinemedicineHumans030212 general & internal medicineSettore SECS-S/05 - Statistica SocialeRandomized Controlled Trials as TopicPharmacologyObserver Variationbusiness.industryGeneral MedicineHepatitis CMiddle Agedmedicine.diseaseHepatitis Cinterferon randomized controlled trials bias trial design favore armTreatment OutcomeResearch Design030220 oncology & carcinogenesisCase-Control StudiesPhysical therapyInterferonsbusinessmedicine.drug
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